-
VHSD
Viral Hepatitle Savaşım Derneği
Comparative Risk of Liver-Related Mortality From Chronic Hepatitis B Versus Chronic Hepatitis C Virus Infection
Oluwaseun Falade-Nwulia1,2, Eric C. Seaberg3, Charles R. Rinaldo4, Sheila Badri6,7, Mallory Witt6,7, and Chloe L. Thio1
+ Author Affiliations
1 Division of Infectious Diseases, Johns Hopkins University, Baltimore
2 Critical Care Medicine Department, National Institutes of Health, Bethesda
3 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland
4 Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pennsylvania
5 Division of Infectious Diseases, John H Stroger Jr Hospital of Cook County, Rush University Medical Center, Chicago, Illinois
6 Department of Medicine
7 Division of HIV Medicine, Harbor-UCLA Medical Center, Torrance, California
Correspondence: Oluwaseun Falade-Nwulia, MD, MPH, Johns Hopkins University, 1830 E Monument St, Rm 420, Baltimore, MD 21287 (ofalade1@jhmi.edu)
Abstract
Background:It is not known whether chronic hepatitis B (CH-B) or chronic hepatitis C (CH-C) carries a greater risk of liver-related mortality. This study compared rates of liver-related mortality between these 2 groups in the Multicenter AIDS Cohort Study (MACS).
Methods:Six hundred eighty men with CH-B (n = 337) or CH-C (n = 343) at study entry into the MACS were prospectively followed to death, last follow-up visit, or 30 March 2010, whichever came first. Four hundred seventy-two (69.4%) of these men were infected with human immunodeficiency virus type 1 (HIV-1). Causes of death were obtained from death registry matching and death certificates. Liver-related and all-cause mortality rates (MRs) were compared between groups using Poisson regression and adjusted for potential confounders and competing risks.
Results:In 6728 person-years (PYs) of follow-up, there were 293 deaths from all causes (43.5 per 1000 PYs), of which 51 were liver-related (7.6 per 1000 PYs). The all-cause MR was similar between those with CH-B and CH-C; however, the liver-related MR was significantly higher in those with CH-B (9.6 per 1000 PYs; 95% confidence interval [CI], 6.9–13.2) than those with CH-C (5.0 per 1000 PYs; 95% CI, 3.0–8.4). In the HIV-infected subgroup, which had 46 (90.2%) of the liver-related deaths, the liver-related MR remained higher from CH-B after adjusting for potential confounders (incidence rate ratio, 2.2; P = .03) and competing risks (subhazard rate ratio, 2.4; P = .02). Furthermore, among HIV-infected subjects, CD4 cell counts <200 cells/mm3 were associated with a 16.2-fold (95% CI, 6.1–42.8) increased risk of liver-related death compared with CD4 cell counts >350 cell/mm3.
Conclusions:Chronic hepatitis B carries a higher risk of death from liver disease than does CH-C, especially in HIV-infected men with greater immunosuppression.
Copyrights © 2017-2023 All Rights Reserved. Powered by vhsd.org
Kişisel Verilerin Korunması Kanununu
Web sitemizin içeriği, ziyaretçiyi bilgilendirmeye yönelik hazırlanmıştır. Sitede yer alan bilgiler, hiçbir zaman bir hekim tedavisinin ya da konsültasyonunun yerini alamaz. Bu kaynaktan yola çıkarak, ilaç tedavisine başlanması ya da mevcut tedavinin değiştirilmesi kesinlikte tavsiye edilmez. Web sitemizin içeriği, asla kişisel teşhis ya da tedavi yönteminin seçimi için değerlendirilmemelidir. Sitede kanun içeriğine aykırı ilan ve reklam yapma kastı bulunmamaktadır.© 2017 - 2023, Tüm hakları saklıdır. Gizlilik Sözleşmesi. Bu web sitesi CEOTECH tarafından yapılmıştır. Daha detaylı bilgi almak için lütfen tıklayınız.