Clin Infect Dis. 2015 Jun 16. pii: civ474.
Hepatitis B Reactivation During Successful Treatment of Hepatitis C with Sofosbuvir and Simeprevir.
Collins JM, Raphael KL, Terry C, Cartwright EJ, Pillai A, Anania FA, Farley MM.
Treatment of HCV with potent, interferon-free, direct acting antiviral regimens with no activity against HBV may increase the risk for HBV reactivation in co-infected patients. We present two cases of HBV reactivation during treatment with an all oral regimen of simeprevir and sofosbuvir and discuss strategies to prevent HBV flare.