 
          38
        
        
          
            Kronik Hepatit B
          
        
        
          2.
        
        
          Ferrari C, Missale G, Boni C, Urbani S. Immunopathogenesis of hepatitis B. J
        
        
          Hepatol 2003;39(Suppl1):S36-42.
        
        
          3.
        
        
          Webster GJ, Reignat S, Maini MK, Whalley SA, Ogg GS, King A et al. Incubation
        
        
          phase of acute hepatitis B in man: dynamic of cellular immune mechanisms.
        
        
          Hepatology 2000;32:1117-1124.
        
        
          4.
        
        
          Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Schreiber R, Chisari FV.
        
        
          Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes.
        
        
          Immunity 1996;4:25-36.
        
        
          5.
        
        
          Tang TJ, Kwekkeboom J, Laman JD, Niesters HG, Zondervan PE, De Man RA et
        
        
          al. The role of  intrahepatic immune effector cells in inflammatory liver injury and
        
        
          viral control during chronic hepatitis B infection. J Viral Hepat 2003;10:159-167.
        
        
          6.
        
        
          Wieland SF, Guidotti LG, Chisari FV. Intrahepatic induction of alpha/beta
        
        
          interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic
        
        
          mice. J Virol 2000;74:4165-4173.
        
        
          7.
        
        
          Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Activated intrahepatic
        
        
          antigen-presenting cells inhibit hepatitis B virus replication in the liver of
        
        
          transgenic mice. J Immunol 2002;169:5188-5195.
        
        
          8.
        
        
          Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Interleukin-18
        
        
          inhibits hepatitis B virus replication in the livers of transgenic mice. J Virol
        
        
          2002;76:10702-10707.
        
        
          9.
        
        
          Lanzavecchia A, Sallusto F. Dynamics of T lymphocyte responses:
        
        
          intermediates, effectors and memory cells. Science 2000;290:92-7.
        
        
          10.
        
        
          Chang JJ, Lewin SR. Immunopathogenesis of hepatitis B virus infection. Immunol
        
        
          Cell Biol 2007;85:16-23.
        
        
          11.
        
        
          Penna A, Artini M, Cavalli A, Levrero M, Bertoletti A, Pilli M et al. Long-lasting
        
        
          memory T cell responses following self-limited acute hepatitis B. J Clin Invest
        
        
          1996;98:1185-1194.
        
        
          12.
        
        
          Thimme R, Wieland S, Steiger C, Ghrayeb J, Reimann KA, Purcell RH et al.
        
        
          CD8(+) T cells mediate viral clearance and disease pathogenesis during acute
        
        
          hepatitis B virus infection. J Virol 2003;77:68-76.
        
        
          13.
        
        
          Kakimi K, Guidotti LG, Koezuka Y, Chisari FV. Natural killer T cell activation
        
        
          inhibits hepatitis B virus replication in vivo. J Exp Med 2000;192:921-930.
        
        
          14.
        
        
          Chisari FV, Isogawa M, Wieland SF. Pathogenesis of hepatitis B virus infection.
        
        
          Pathol Biol (Paris) 2010; 58:258-266.
        
        
          15.
        
        
          Maini MK, Boni C, Ogg GS, King AS, Reignat S, Lee CK, et al. Direct ex vivo
        
        
          analysis of hepatitis B virus-specific CD8 T cells associated with the control of
        
        
          infection. Gastroenterology 1999;117:1-13.
        
        
          16.
        
        
          Parker DC. T cell-dependent B cell activation. Annu Rev Immunol 1993;11:331-60.
        
        
          17.
        
        
          Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Ann Rev Immunol
        
        
          1995;13:29-60.
        
        
          18.
        
        
          Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A. Is a function
        
        
          of the secreted hepatitis B e antigen to induce immunologic tolerance in utero?
        
        
          Proc Natl Acad Sci USA 1990;87:6599-604.
        
        
          19.
        
        
          Maini M, Boni C, Lee C, Larrubia J, Reignat S, Ogg G et al. The role of virus-
        
        
          specific CD8(+) cells in liver damage and viral control during persistent hepatitis
        
        
          B virus infection. J Exp Med 2000;191:1269-1280.
        
        
          20. Chen MT, Billaud JN, Sallberg M, Guidotti LG, Chisari FV, Jones J, et al. A
        
        
          function of the hepatitis B virus precore protein is to regulate the immune
        
        
          response to the core antigen. Proc Natl Acad Sci USA 2004;101:14913-8.